When I first got osteoporosis, I was hoping to make my bones stronger. I thought I could stop my bone loss, but I didn’t know it was possible to do more. Then my doctor told me once-monthly BONIVA works with your body to help stop and reverse bone loss. In fact, studies show after one year on BONIVA,

9 out of 10 women reversed their bone loss. And my test results proved I did, too.*

†

Ask your doctor if BONIVA is right for you.

And for a free trial offer, call 1-866-571-6892 or visit tryBONIVA.com

BONIVA is a prescription medication for the management of postmenopausal osteoporosis.

Important Safety Information: You should not take BONIVA if you have low blood calcium, cannot sit or stand for at least 60 minutes, have severe kidney disease, or are allergic to BONIVA. Stop taking BONIVA and tell your doctor right away if you experience difficult or painful swallowing, chest pain, or severe or continuing heartburn, as these may be signs of serious upper digestive problems. Follow the dosing instructions for once-monthly BONIVA carefully to lower the chance of these events occurring. Side effects may include diarrhea, pain in the arms or legs, or upset stomach. Tell your doctor and dentist about all the medicines you take. Tell them if you develop jaw problems (especially following a dental procedure) or severe bone, joint, and/or muscle pain. Your doctor may also recommend a calcium and vitamin D supplement.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

*Bone density measured at the lumbar spine after1year of treatment.

Individual results may vary.

^†Bone density measured at the lumbar spine, total hip, or trochanter;

3 out of 4 at the femoral neck.

Please read Patient Information on the next page.

BONIVA and symbol are trademarks of Roche Therapeutics Inc. © 2008 Roche Laboratories Inc. All rights reserved.